Highmark Commercial Medical Policy - Pennsylvania

Medical Policy: L-191-003
Topic: Intracellular Micronutrient Testing Panel
Section: Laboratory
Effective Date: November 13, 2017
Issue Date: July 9, 2018
Last Reviewed: June 2018

Intracellular micronutrient testing (also known as: micronutrient testing, essential metabolic analysis, leukocyte nutrient analysis, functional micronutrient analysis) is a novel lab panel that measures the intracellular level of multiple nutrients. Micronutrients measured by this test include but are not limited to the following:

  • Vitamins- A, B1, B2, B3, B6, B12, C, D, K. E
  • Biotin, Folate, Pantothenate,
  • Minerals- Calcium, Magnesium, Manganese, Zinc, Copper
  • Amino Acids- Asparagine, Glutamine, Serine
  • Fatty acids, Oleic Acid
  • Antioxidants -Alpha Lipoic Acid, Coenzyme Q10, Cysteine, Glutathione, Selenium
  • Carbohydrate Metabolism- Chromium, Fructose Sensitivity, Glucose-Insulin Metabolism
  • Metabolites- Choline, Inositol. Carnitine
  • Total antioxidant function and immune Response Score (offered by SpectrCell Laboratories)

This policy is designed to address medical guidelines that are appropriate for the majority of individuals with a particular disease, illness, or condition. Each person's unique clinical circumstances may warrant individual consideration, based on review of applicable medical records.

Policy Position Coverage is subject to the specific terms of the member’s benefit plan.

Intracellular micronutrient testing panel is considered experimental/investigational, and therefore, non-covered.  There is insufficient evidence in the published peer-reviewed medical evidence to support health outcomes or effectiveness of this test.

Procedure Codes
82136, 82180, 82306, 82310, 82379, 82495 , 82525, 82607, 82652, 82725, 82746, 82978, 83735, 83785, 84207, 84252, 84255, 84425, 84446, 84590, 84591, 84597, 84630, 84999, 86353, 88348

Place of Service: Outpatient

Experimental/Investigational (E/I) services are not covered regardless of place of service.

The policy position applies to all commercial lines of business

Denial Statements

Services that do not meet the criteria of this policy will be considered experimental/investigational (E/I). A network provider can bill the member for the experimental/investigational service. The provider must give advance written notice informing the member that the service has been deemed E/I. The member must be provided with an estimate of the cost and the member must agree in writing to assume financial responsibility in advance of receiving the service. The signed agreement must be maintained in the provider’s records.


Medical policies do not constitute medical advice, nor are they intended to govern the practice of medicine. They are intended to reflect Highmark's reimbursement and coverage guidelines. Coverage for services may vary for individual members, based on the terms of the benefit contract.

Discrimination is Against the Law
The Claims Administrator/Insurer complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex. The Claims Administrator/Insurer does not exclude people or treat them differently because of race, color, national origin, age, disability, or sex. The Claims Administrator/ Insurer: If you need these services, contact the Civil Rights Coordinator.

If you believe that the Claims Administrator/Insurer has failed to provide these services or discriminated in another way on the basis of race, color, national origin, age, disability, or sex, you can file a grievance with: Civil Rights Coordinator, P.O. Box 22492, Pittsburgh, PA 15222, Phone: 1-866-286-8295, TTY: 711, Fax: 412-544-2475, email: CivilRightsCoordinator@highmarkhealth.org. You can file a grievance in person or by mail, fax, or email. If you need help filing a grievance, the Civil Rights Coordinator is available to help you.

You can also file a civil rights complaint with the U.S. Department of Health and Human Services, Office for Civil Rights electronically through the Office for Civil Rights Complaint Portal, available at https://ocrportal.hhs.gov/ocr/portal/lobby.jsf, or by mail or phone at:

U.S. Department of Health and Human Services
200 Independence Avenue, SW
Room 509F, HHH Building
Washington, D.C. 20201
1-800-368-1019, 800-537-7697 (TDD)

Complaint forms are available at http://www.hhs.gov/ocr/office/file/index.html.

Insurance or benefit/claims administration may be provided by Highmark, Highmark Choice Company, Highmark Coverage Advantage, Highmark Health Insurance Company, First Priority Life Insurance Company, First Priority Health, Highmark Benefits Group, Highmark Select Resources, Highmark Senior Solutions Company or Highmark Senior Health Company, all of which are independent licensees of the Blue Cross and Blue Shield Association, an association of independent Blue Cross and Blue Shield plans.

Highmark retains the right to review and update its medical policy guidelines at its sole discretion. These guidelines are the proprietary information of Highmark. Any sale, copying or dissemination of the medical policies is prohibited; however, limited copying of medical policies is permitted for individual use.